Top 20 Healthcare Common Procedure Coding System Codes Used
Looking for the most used Healthcare Common Procedure Coding System codes in 2025? Whether you're billing for office visits, medications, or equipment, choosing the right codes helps reduce denials and speed up payments.
This guide highlights 21 of the most frequently billed Healthcare Common Procedure Coding System Codes across specialties—so you can submit cleaner claims and stay aligned with payer expectations.
Here are the Top 21 Healthcare Common Procedure Coding System Codes Used in 2025
Commonly Used Office and Outpatient Visit Codes
1. G0462 – Office Visits in Rural Health Clinics
G0462 is part of the Healthcare Common Procedure Coding System Codes used to bill follow-up evaluation and management services provided in rural health clinics. It’s typically applied when an established patient returns for chronic condition checkups or ongoing care.
2. G0460 – General medical visits in community health centers
This code is billed for general E&M services at Federally Qualified Health Centers (FQHCs). It covers comprehensive care such as physical exams, history reviews, and plan-of-care discussions in low-income or underserved areas. For more details on how these and other related codes are used, refer to this guide on service codes for medical billing.
3. G0318 – Outpatient respiratory therapy services
This code is used when outpatient clinics provide therapeutic respiratory services, often for patients with asthma, COPD, or post-COVID complications. It supports billing for medically necessary, clinic-based pulmonary care.
4. G0463 – Hospital outpatient clinic visit billing
G0463 is an Healthcare Common Procedure Coding System Codes used by hospitals to bill outpatient evaluation and management services. It is widely adopted in facility-based billing and includes administrative overhead, staffing, and clinic use.
| HCPCS Code | Description | Common Use Case |
|---|---|---|
| G0462 | Rural health clinic visits | Follow-ups for chronic care |
| G0460 | Community health center visits | General exams in FQHCs |
| G0318 | Respiratory therapy (outpatient) | Asthma, COPD, post-COVID care |
| G0463 | Hospital outpatient clinic visits | Facility-based E/M billing |
| G0439 | Medicare wellness (follow-up) | Annual risk check for Medicare patients |
Emergency and High-Severity Evaluation Codes
5. G0382 – High-severity emergency department visit (Level III facility)
HCPCS G0382 is used for facility billing when patients present in the emergency department with serious conditions requiring moderate to high complexity evaluation and management. This code reflects substantial diagnostic workup, resource use, and aligns with outpatient facility E/M guidelines outpatient facility E/M guidelines under the Healthcare Common Procedure Coding System (HCPCS).
6. A0428 – Used for non-emergency BLS ambulance transport
HCPCS A0428 is billed by EMS services when basic life support is required, but the transport is not classified as an emergency. It applies to routine hospital transfers and outpatient procedures.
Preventive and Medicare Wellness Visit Codes
7. G0438 – Initial Medicare Annual Wellness Visit
HCPCS G0438 is used for the first annual wellness visit under Medicare Part B (after the first 12 months of enrollment). It includes a comprehensive health risk assessment, personalized prevention plan, and establishes patient baseline—capturing what earlier CPT codes aimed to bill.
8. G0439 – Medicare annual wellness visit (subsequent)
G0439 is used for follow-up Medicare wellness visits after the initial G0438. It includes updating medical history, evaluating risk factors, and care coordination without a physical exam.
9. G0008 – Flu vaccine administration billing
This code is billed for administering the seasonal influenza vaccine to Medicare patients. G0008 is used in pharmacies, urgent care centers, and outpatient clinics during flu season.
10. G0121 – Screening colonoscopy for colorectal cancer
G0121 supports billing for preventive colonoscopy screenings in average-risk Medicare patients. It helps detect colorectal cancer early and is part of most insurance wellness coverage.
Drug and Injection Billing Codes
11. J3490 – Used for unclassified medication billing
When a medication does not have a specific Healthcare Common Procedure Coding System Codes, J3490 is used. It requires supporting documentation and is especially common in oncology and specialty drug billing.
‘’Unclassified drugs: because the government still needs time to catch up to your pharmacist.’’
12. J1885 – Billed for ketorolac injections (pain control)
This code, listed under the Healthcare Common Procedure Coding System Codes, is billed per 15 mg of ketorolac tromethamine, a non-opioid injectable pain reliever used post-surgery or for acute conditions in ER settings.
13. J1100 – Dexamethasone injection for inflammation
HCPCS J1100 is billed for injectable dexamethasone, a corticosteroid used to reduce inflammation in orthopedic, ENT, or allergy-related procedures.
14. J3010 – Injectable fentanyl for anesthesia use
Anesthesiologists and pain clinics bill J3010, one of the Healthcare Common Procedure Coding System Codes, for injectable fentanyl citrate used during surgeries or in post-operative pain management.
15. J0702 – Steroid injection billing for joint pain
This code is used for betamethasone sodium phosphate and acetate injections. It is popular among orthopedic and rheumatology providers treating inflammation or arthritis.
Most Used Injection & Drug Billing Codes
| Code | Medication | Billing Scenario |
|---|---|---|
| J1885 | Ketorolac injection (per 15 mg) | Pain control post-surgery |
| J3010 | Fentanyl citrate | Anesthesia and sedation use |
| J1100 | Dexamethasone injection | Inflammation and allergy care |
| J3490 | Unclassified drug | Non-specified or new drug billing |
| J0702 | Betamethasone injection | Rheumatology and joint pain therapy |
Durable Medical Equipment and Therapy Codes
16. E0110 – Used to bill for underarm crutches
Billed by orthopedic practices and DME suppliers, E0110 covers standard underarm crutches provided post-surgery or injury.
17. B9002 – Applied for enteral nutrition infusion pumps
This code is billed for enteral feeding pumps prescribed to patients requiring long-term nutritional therapy via feeding tubes.
18. E0601 – CPAP machine billing for sleep apnea
Sleep clinics and home health agencies use E0601 to bill for Continuous Positive Airway Pressure (CPAP) devices used to treat obstructive sleep apnea.
‘’If you think CPT codes are confusing, try asking a sleep-deprived coder to explain E1399 at 3 AM’’
19. Q4101 – Skin substitute (Apligraf) billing for wounds
Q4101 is used when applying Apligraf skin grafts in wound care. It helps treat diabetic foot ulcers and venous leg ulcers in outpatient care.
Behavioral Health and Risk Counseling Codes
20. 99406 – Counseling for smoking and tobacco cessation
This code supports 3–10 minute intermediate counseling sessions aimed at helping patients quit smoking. It is reimbursed under most Medicare and commercial plans.
How to Use These HCPCS Codes Correctly in Your Billing Workflow
To use Healthcare Common Procedure Coding System Codes correctly, to align each code with payer policies, medical documentation, and required modifiers. Start by checking the latest CMS updates and verify if the code is covered under the patient’s plan. Ensure the units and modifiers match the service provided, and that the clinical documentation supports the billing. Errors like using J3490 without dosage details can lead to denials. A quick coding audit can help avoid costly mistakes.
Using the right Healthcare Common Procedure Coding System Codes makes a big difference. These top 21 codes reflect what providers are actually billing—and what payers expect to see. When integrated properly into your medical billing services, they help reduce denials, improve claim accuracy, and support faster reimbursements.
Getting them wrong could mean delays or denials. Getting them right? That’s faster payments.
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